Dr. Keshab Bora, Dr. Sanjeeb Kakati, Dr. Subhalakshmi Das, Dr. Lipee Nath


Increased risk of atherosclerosis in type 2 diabetics has been attributed to high prevalence of multiple atherosclerotic risk factors.
A hospital based case-control study was conducted for 2 years to compare the serum levels of inflammatory biomarkers in newly
diagnosed type 2 diabetics with healthy controls, to find out the correlation of these biomarkers with cardiovascular risk factors,
and to observe the association of these biomarkers with atherosclerotic changes evidenced by Carotid Intimo-Medial Thickness
(CIMT). Out of total 80 subjects, 40 healthy individuals were taken as control group and 40 cases of newly diagnosed patients with
type 2 diabetes mellitus were taken as test group. The inflammatory biomarkers analysed were IL6, IL18, fibrinogen and hsCRP.
ApoB and lipid profile were taken as cardiovascular risk factors. CIMT was measured by Doppler ultrasonography. The mean
serum FBS, PPBS, HbA1C, lipid profile, ApoB and inflammatory biomarkers were significantly raised in test group compared to the
control group. Significant positive correlation have been found between cardiovascular risk factors (ApoB, Total cholesterol, LDLC)
and inflammatory biomarkers. The inflammatory biomarkers are also positively correlated with CIMT. The study concluded that
inflammatory biomarkers are associated with type 2 diabetes mellitus and lead to increased intimo-medial thickening of the
carotid arteries.


Case Control Study, Inflammatory Biomarkers, Cimt, Cardiovascular Risk Factors

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Libby P, Ridker PM, Maseri A. Inflammation and Atherosclerosis. Circulation 2002;105:1135-43.

Clarke R, Emberson JR, Breeze E, Casas JP, Parish S, Hingorani AD et al. Biomarkers of inflammation predict both vascular and non- vascular mortality in older men. Eur Heart J 2008 Mar;29(6):800-9.

Dhastagir SS, Sachu P, Elshaari FA. HDL apoB/apo A1 ratio Diabetes Mellitus and Cardiovascular Disease. In: Masuo K, editor. Type 2 Diabetes. Croatia: InTech; 2013. p. 171-201.

Fox CS, Coady S, Sorlie PD, Levy D, Meigs JB, D’Agostino RB Sr et al. Trends in cardiovascular complications of diabetes. JAMA 2004 Nov 24;292(20):2495-9.

Valiollah S, Mojtaba E, Vahid I, Ali SM. Association of C Reactive Protein with Insulin Resistance in Type II Diabetic. IPCBEE 2011;5:407-9.

Schmidt AM, Yan SD, Wautier JL, Stern D. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 1999 Mar 19;84(5):489-97.

Pickup JC. Inflammation and activation innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004 Mar;27(3):813-23.

Dezayee ZMI. Interleukin-18 can predict pre-clinical atherosclerosis and poor glycemic control in type 2 diabetes mellitus.Int J Appl Basic Med Res 2011;1:109-112.

Bosevski M, Bosevska G, Stojanovska L. Influence of fibrinogen and C-RP on progression of peripheral arterial disease in type 2 diabetes: a preliminary report. CardiovascDiabetol 2013 Feb 1;12:29.

Silva D, Pais de Lacerda A.High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease.Rev Port Cardiol 2012 Nov;31(11):733-45.

Olofesson SO, Wiklund O, Boren J. Apolipoprotein A1 and B: biosynthesis, role in the development of atherosclerotic and target for intervention against cardiovascular disease. Vasc Health Risk Manag 2007August;3(4):491-502.

Ahmad J, Ahmed F, Siddique MA, Khan AR, Katyal P, Hameed B et al. Inflammatory markers, Insulin resistance and carotid intima-media thickness in North-Indian type 2 diabetic subjects. J Assoc Physicians India 2007 Oct;55:693-98.

Aso Y, Okumura K, Takebayashi K, Wakabayashi S, Inikai T. Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes. Diabetes Care 2003 Sep;26(9):2622-7.

Leinonen ES, Hiuukka A, Hurt-Camejo E, Wilkund O, Sarna SS, Hulten LM et al. Low grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes. Journal of Internal Medicine 2004;256:119-127.

Haffner SM, D’Agostino R Jr, Saad MF, O’Leary DH, Savage PJ, Rewers M et al. Carotid artery atherosclerosis in type 2 diabetic and non-diabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study). Am J Cardiol 2000 Jun 15;85(12):1395-400.

Haffner SM. Insulin resistance, inflammation, and the prediabetic state. Am J Cardiol 2003 Aug 18;92(4A):18J-26J.


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