ASSOCIATION OF INFLAMMATORY BIOMARKERS IN NEWLY DIAGNOSED TYPE 2 DIABETICS WITH ATHEROSCLEROTIC CHANGES.

Dr. Keshab Bora, Dr. Sanjeeb Kakati, Dr. Subhalakshmi Das, Dr. Lipee Nath

Abstract


Increased risk of atherosclerosis in type 2 diabetics has been attributed to high prevalence of multiple atherosclerotic risk factors.
A hospital based case-control study was conducted for 2 years to compare the serum levels of inflammatory biomarkers in newly
diagnosed type 2 diabetics with healthy controls, to find out the correlation of these biomarkers with cardiovascular risk factors,
and to observe the association of these biomarkers with atherosclerotic changes evidenced by Carotid Intimo-Medial Thickness
(CIMT). Out of total 80 subjects, 40 healthy individuals were taken as control group and 40 cases of newly diagnosed patients with
type 2 diabetes mellitus were taken as test group. The inflammatory biomarkers analysed were IL6, IL18, fibrinogen and hsCRP.
ApoB and lipid profile were taken as cardiovascular risk factors. CIMT was measured by Doppler ultrasonography. The mean
serum FBS, PPBS, HbA1C, lipid profile, ApoB and inflammatory biomarkers were significantly raised in test group compared to the
control group. Significant positive correlation have been found between cardiovascular risk factors (ApoB, Total cholesterol, LDLC)
and inflammatory biomarkers. The inflammatory biomarkers are also positively correlated with CIMT. The study concluded that
inflammatory biomarkers are associated with type 2 diabetes mellitus and lead to increased intimo-medial thickening of the
carotid arteries.


Keywords


Case Control Study, Inflammatory Biomarkers, Cimt, Cardiovascular Risk Factors

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References


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