TUBERCULOUS MENINGITIS IN BCG VACCINATED AND UNVACCINATED CHILDREN A CLINICAL AND RADIOLOGICAL COMPARATIVE STUDY

Dr. Sikha Maria Siromani, Dr. Srilakshmi

Abstract


Tuberculous Meningitis is the most serious form of Tuberculosis in children the main aim of this study is to assess protective role of
BCG vaccination in TBM and compare clinical and radiological features in BCG vaccinated and unvaccinated children. We have
done a prospective study in Niloufer Hospital in the year 2016-17. Out of 108 children taken into study 66 were vaccinated 42
were unvaccinated.
Materials and Methods: Children who were taken into the study satisfied the pre-defined criteria for diagnosis of TBM provided
they have not received anti tubercular treatment in the last three months.
Results: The analysis showed that the vaccinated children with BCG scar had more focal deficits compared to unvaccinated
children. The CT findings show more children with basal enhancement in vaccinated children.
Conclusion: Our study indicates that the outcome of TBM was similar in both BCG vaccinated and unvaccinated children. The
better outcome may in part be explained by better mobilization of cell mediated immune response to the infection as reflected in
high mean CSF cell count in vaccinated children.


Keywords


TBM, BCG

Full Text:

PDF

References


World Health Organization Joint Tuberculosis Program Review, India, February 2000. New Delhi: WHO Regional Office for South East Asia.

Rao S P Bharambe MS. Vaccine preventable diseases in Eastern Maharashtra; a hospital based analysis, Indian Pediatrics 1991;28:629-633.

Somu N, Vijayasekaran D, Rajkumar T, et al Tuberculous disease in a pediatric referral center-16 years experience. Indian Pediatrics 1994;31:1245-1249.

Kumar P, Kumar R, Srivastava K L et al. Protective role of BCG vaccination against Tuberculous Meningitis in Indian Children; reappraisal. Natl Med J India 2005;18:7-11.

Paul MF. Tuberculosis in BCG vaccinated children in Singapore, Arch Dis Child 1961;36:530-536.

Tandon PN, Singh B, Mahapatra LN, et al, Experimental tuberculosis of central nervous system. Nuerol India 1970;18:81-85

Kumar R, Dwivedi A, Kumar P, KohliN.Tuberculous meningitis in BCG vaccinated and unvaccinated children. J NuerolNeurosurg Psychiatry.2005 No;76(11):1550-1554

Raju VB, Narmada R. Evaluation of BCG vaccination in children below 6 years. Indian Pediatrics 1970;7:532-541.

Deshpande NS, Deshpande SV. Tuberculosis in BCG vaccinated children Indian Pediatrics 1995;32:676-678.

Udani PM, Parekh UC, Dasfur DK. Some neurological syndromes in CNS tuverculosis, Neurol India 1972;Suppl:63-69.


Refbacks

  • There are currently no refbacks.