BIOCHEMICAL APPROACH TO THE DIFFERENTIAL DIAGNOSIS OF METABOLIC ACIDOSIS IN CRITICALLY ILL- CHILDREN.

Dr. Aruna Kumari Bandaru

Abstract


Objective: The aim of the study was to simplify the arterial blood gas analysis and facilitate the differential diagnosis of metabolic
acidosis (MA) in critically ill- children.
Methods: A descriptive study was conducted on 150 children admitted in the pediatric intensive care unit were analyzed for acidbase
status. The Anion Gap (AG) was calculated elta gap and Delta ratio to assess to identify the causes of MA. D used the presence
of mixed acid-base disorders.
Results: - There was a significant decrease in means of PH, Bicarbonate (HCO ), and Base Excess, while there is increase in AG 3
- - + between the MA and control groups. There was a significant decrease in HCO , Chloride, and Chloride: Sodium (Cl /Na ) ratio, 3
while there was a significant increase in AG, Delta Gap, and Delta Ratio in high AGMA than Normal AGMA.
Conclusion: - + Cl /Na ratio, Delta Gap and Delta Ratio can be used as indicators in differentiating MA.


Keywords


Anion Gap, Delta Gap, Delta Ratio, High Anion Gap Metabolic Acidosis.

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References


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