Baig MQ, Khan Mamun, Wahikar Shilpa


The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy in modern oncology treatment, the
protein kinases are responsible for cellular transduction cell signaling and their hyper activity malfunction or over expression can
be found in various types of malignancies .


cell signaling , Targeted therapies

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-Perkins, N. D. Oncogenes, tumor suppressors and p52 NF-κB. Oncogene 22, 7553–7556 (2003).

-. Lin, L., DeMartino, G. N. & Greene, W. C. Cotranslational biogenesis of NF-κB p50 by the 26S proteasome. Cell 92, 819–828 (1998).

-. Cohen, S., Achbert-Weiner, H. &Ciechanover, A. Dual effects of IκB kinase β-mediated phosphorylation on p105 fate: SCF(β-TrCP)-dependent degradation and SCF(β-TrCP)-independent processing. Mol. Cell. Biol. 24, 475–486 (2004).

-Druker Brian J., et al. "Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia." The New England Journal of Medicine 344, no. 14 (2001): 1031–1037.

-Goldman, John M., and Junia V. Melo. "Targeting the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia." The New England Journal of Medicine 344, no. 14 (2001): 1084–1086.

-. Nowell, P., J. Rowley, and A. Knudson. "Cancer Genetics, Cytogenetics—Defining the Enemy Within." Nature Medicine 4 (October 1998): 1107–1114.

-. Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T. &Grumont, R. Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18, 6888–6895 (1999).

-. Pasparakis, M., Luedde, T. & Schmidt-Supprian, M. Dissection of the NF-κBsignalling cascade in transgenic and knockout mice. Cell Death Differ. 13, 861–872 (2006). Genetic experiments in mice provide much of the basis for our understanding of the NF- 9-κB and IKK pathway. Reference 3 summarizes fundamental information about different NF-κB-, IκB- and IKK-knockout mouse phenotypes. Reference 4 describes how these mice have been used to study the role of the NF-κB and IKK pathway in physiological processes and human diseases. These reviews are both essential reading.

-. Pahl, H. L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853–6866 (1999).

-. Perkins, N. D. & Gilmore, T. D. Good cop, bad cop: the different faces of


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