Taufik Sungkar, Masrul Lubis, Gontar Alamsyah Siregar, Ginanda Putra Siregar


The main pathogenesis of gastritis and gastric cancer are inflammation process and the role of free radicals. Chronic inflammation
can lead a gastric mucosa to be atrophy that can develop into intestinal metaplasia and dysplasia, and finally develop into gastric
cancer. Malondialdehyde (MDA) is a free radical biomarker and found increased on both gastritis and gastric cancer. The purpose
of this study was to determine differences of serum MDA levels in gastritis patients with and without gastric premalignant lesion.
This cross sectional study was conducted in endoscopic unit of Adam Malik General Hospital Medan from April to June 2018.
Gastric premalignant lesion diagnosis was made when one or more of the following were present: chronic atrophic gastritis,
intestinal metaplasia, or dysplasia. A plasma MDA examination was performed using an HPLC MDA kit. Data were statistically
analyzed. There were significant differences MDA levels in gastritis between with and without gastric premalignant lesion (p =
0.024). MDA levels in gastritis patients with gastric premalignant lesion were higher than without premalignant gastric lesion.


Gastric premalignant lesion, malondialdehyde, gastritis

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El-Zimaity HMT. Recent advances in the histopathology of gastritis. Curr Diagn Pathol.2007;13:340-8.

Ohata H,et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer.2004;109(1):138-43.

Song H,et al. Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population. BMJ. 2015: 351 3867.

Sipponen P, Maaroos HI. Chronic gastritis. Scand J Gastroenterol.2015;50:657-67

Zhang C, Yamada N, Wu Y. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer. World J Gastroenterol. 2005;11:791-6.

Dinis-Ribeiro M,et al. Management of precancerous conditions andlesions in the stomach (MAPS): guideline from the European Society ofGastrointestinal Endoscopy (ESGE), European Helicobacter Study Group(EHSG), European Society of Pathology (ESP), and the SociedadePortuguesa de Endoscopia Digestiva (SPED). Endoscopy. 2012;44:74-94.

Demir S,et al.Role of free radicals in peptic ulcer and gastritis. Turk J Gastroenterol. 2003;14:39-43.

Tiwari SK,et al. Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels. Inflammopharmacol. 2010;18:59-64.

Arkhaesi N. Kadar malondialdehyde serum sebagai indikator prognosis keluaran pada sepsis neonatorum. Semarang: Departemen Ilmu Kesehatan Anak FK Undip;2008. p12-22.

Rugge M,et al. Gastritis: the histology report. Dig Liver Dis. 2011;43S:373–84.

Immundiagnostik AG.Malondialdehyde HPLC Kit. 2010 [cited 10 Desember2016]. Available from:http://immundiagnostik.com/fileadmin/pdf/Malondialdehyd_KC1900.pdf

Elsawaf ZM, Albasri AM, Hussainy AS. Histopathological pattern of benign endoscopic gastric biopsies in Western Saudi Arabia: a review of 1236 cases. J Pak Med Assoc.2017;67:252-5.

Takao T,et al. Multifaceted assessment of chronic gastritis: a study of correlations between serological, endoscopic, and histological diagnostics. Gastroenterol Res Pract. 2011: Article ID631461.

Choudhury S, Laishram RS, Punyabati P. Histopathological study of gastric mucosal biopsies in chronic gastritis patients with special correlation to Helicobacter pylori infection at Rims Hospital. J Evid Based Med Health. 2016;3:2829-35.

Siregar GA, Halim S, Sitepu RR. Serum TNF-α, IL-8, VEGF levels in Helicobacter pylori infection and their association with degree of gastritis. Acta Med Indones. 2015;47: 120-6.

Li J,et al.Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration. Genetics and Molecular Research.2015;14:4361-8.

Joseph RM, Varela V, Kanji VK. Protective effects of zinc in indomethacin-induced gastric mucosal injury: evidence for a dual mechanism involving lipid peroxidation and nitric oxide. Aliment PharmacolTher. 1999;13:203-8.

Santra A, Chowdhury A, Chaudhuri S. Oxidative stress in gastric mucosa in Helicobacter pylori infection. Indian J Gastroenterol. 2000;19:21-3.

Bitla AR, Reddy EP, Sambasivaih K. Evaluation of plasma malondialdehyde as a biomarker in patients with carcinoma of stomach. Biomed Res.2011;22:63-8.

Darmadi, Siregar GA, Dairi LB. Association between degree of Gastritis and Malondialdehyde level of Gastritis patients at Adam Malik General Hospital Medan. IndonesJ Gastroenterol Hepatol Dig Endosc.2017;18(2):80-6.


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