DIFFERENCES OF SERUM MALONDIALDEHYDE LEVELS IN GASTRITIS PATIENTS WITH AND WITHOUT GASTRIC PREMALIGNANT LESION

Taufik Sungkar, Masrul Lubis, Gontar Alamsyah Siregar, Ginanda Putra Siregar

Abstract


The main pathogenesis of gastritis and gastric cancer are inflammation process and the role of free radicals. Chronic inflammation
can lead a gastric mucosa to be atrophy that can develop into intestinal metaplasia and dysplasia, and finally develop into gastric
cancer. Malondialdehyde (MDA) is a free radical biomarker and found increased on both gastritis and gastric cancer. The purpose
of this study was to determine differences of serum MDA levels in gastritis patients with and without gastric premalignant lesion.
This cross sectional study was conducted in endoscopic unit of Adam Malik General Hospital Medan from April to June 2018.
Gastric premalignant lesion diagnosis was made when one or more of the following were present: chronic atrophic gastritis,
intestinal metaplasia, or dysplasia. A plasma MDA examination was performed using an HPLC MDA kit. Data were statistically
analyzed. There were significant differences MDA levels in gastritis between with and without gastric premalignant lesion (p =
0.024). MDA levels in gastritis patients with gastric premalignant lesion were higher than without premalignant gastric lesion.


Keywords


Gastric premalignant lesion, malondialdehyde, gastritis

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