Dr M. Lakshmi Narayana, Dr S.M Azeem Mohiyuddin, Dr Shilpa MD, Dr Divya Jyothi N


Primary cuteanous lymphomas are one of the extra nodal types of Non-Hodgkin's Lymphoma. Primary cutaneous lymphomas are
mainly divided into B-cell and T-cell. B-cell Follicle centre Lymphoma is most common of all B-cell lymphomas. We present a 38
year old lady who came with an erythematous firm swelling in the right infra orbital region. FNAC showed features of acute and
chronic inflammatory cells. The lesion was excised and histopathology showed features of lymphoid follicle formation with
centrocytes and centroblasts in dermis and subcutaneous tissue. Immunohistochemistry showed neoplastic nodules positive for
CD20, Mum-1, BCL-6 and negative for BCL-2, CD79a, CD10 and CD43. All these features were consistent with follicular variant
of follicle centre lymphoma, which is rare. Postoperative PET-CT didn't show any uptake elsewhere. The patient was disease free
and was on regular follow up since 2 years. Cutaneous lymphomas are rare and have an indolent course when compared with
nodal lymphomas. Primary cutaneous Follicle centre B-cell lymphoma has a good prognosis with a 5-year survival rate up to 95%
but do have local recurrences.


Cutaneous lymphoma, Infraorbital region, Follicle centre cell, Immunohistochemistry.

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Burg G, Kempf W, Kazakov DV, Michaelis S, Dummer R. Burg G, Kempt W.Cutaneous lymphomas. Florida: Taylor & Francis Group; 2005. WHO/EORTC Classification of Cutaneous Lymphomas; pp. 91–92.

Harris NL, Jaffe ES, Stein J, Banks PM, Chan JKC, Cleary ML, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361–92.

Willemze R, Kerl H, Sterry W, Berti E, Cerroni L, Chimenti S, Diaz-Peréz JL, Geerts ML, Goos M, Knobler R, Ralfkiaer E, Santucci M, Smith N, Wechsler J, van Vloten WA, Meijer CJ. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood. 1997 Jul 1;90(1):354-71.

Cerroni L, Arzberger E, Pütz B, Höfler G, Metze D, Sander CA, Rose C, Wolf P, Rütten A, McNiff JM, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood. 2000 Jun 15;95(12):3922-8.

Viguier M, Rivet J, Agbalika F, Kerviler E, Brice P, Dubertret L, Bachelez H:B-cell lymphomas involving the skin associated with hepatitis C virus

infection. Int J Dermatol 2002, 41:577–582.

Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C, MyskowskiPL.Primary cutaneous B-cell lymphomas: part I. Clinical features, diagnosis, and classification. J Am AcadDermatol. 2013 Sep;69(3):329.e1-13; quiz 341-2.

Bekkenk MW, Postma TJ, Meijer CJ, Willemze R: Frequency of central

nervous system involvement in primary cutaneous B-cell lymphoma.

Cancer 2000, 89:913–919.

Hoefnagel JJ, Vermeer MH, Jansen PM, Fleuren GJ, Meijer CJ, Willemze R: Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance. Br J Dermatol 2003, 149:1183–1191.

Wanczinski MI, Pinto CAL, Trevisan F, Cunha PR, Grohs LMH. Primary cutaneous follicle center lymphoma simulating basal-cell carcinoma on the nasal ala.An Bras Dermatol. 2015;90 (3 Suppl 1):S111-4.

Ceovic et al.: Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. Radiation Oncology 2013 8:147.


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