TO STUDY THE INCIDENCE OF GROUP V PULMONARY HYPERTENSION IN CKD V PATIENTS ON MAINTANANCE HEMODIALYSIS AT OUR CENTRE

Agarwal A, Pahwa N, Vohra R

Abstract


BACKGROUND: The incidence of chronic kidney disease in India is around 17.4%. Pulmonary hypertension is common in dialysis
dependent chronic kidney disease patients, which in turn increase the risk of cardiovascular complications.
AIMS AND OBJECTIVES: Evaluation of Group V pulmonary hypertension in chronic kidney disease stage V patients on
maintenance hemodialysis.
MATERIAL AND METHODS: The present observational,prospective study was conducted from April 2016 to October 2017 on
100 patients of chronic kidney disease stage V on maintenance hemodialysis. Pregnant woman, patients on PAH medication were
excluded from the study. The patients with pulmonary hypertension came for follow-up after 3 months. For classification of
chronic kidney disease - National Kidney Foundation Classification was used. For diagnosis of pulmonary hypertension, diagnostic
criteria given by RHC was used.
RESULTS: There were 36.84% females and 63.16% males, while in the pulmonary hypertension group, there were 20.83%
females and 79.17% males, showing a male preponderance. The mean age comparison (47.8 ± 14.1 years vs. 49.0 ± 17.9 years in
non-pulmonary and pulmonary hypertension) was found to be statistically not significant (p>0.05). The mean hemoglobin level
comparison (9.43 ± 1.76 gm% vs. 9.11 ± 1.27 gm% in non-pulmonary and pulmonary hypertension) was found to be statistically
not significant (p>0.05).The mean systolic blood pressure comparison (150.3 ± 18.3 mm Hg vs. 153.8 ± 18.1 mm Hg in nonpulmonary
and pulmonary hypertension) was found to be statistically not significant (p>0.05).The mean diastolic blood pressure
comparison (90.0 ± 10.3 mm Hg vs. 93.8 ± 11.3 mm Hg in non-pulmonary and pulmonary hypertension) was found to be
statistically not significant (p>0.05).The mean body mass index comparison (21.57 ± 4.11 kg/m2 vs. 20.65 ± 3.79 kg/m2 in nonpulmonary
and pulmonary hypertension) was found to be statistically not significant (p>0.05).The mean serum
creatininecomparison (8.95 ± 3.55 mg/dL vs. 8.10 ± 2.31 in non-pulmonary and pulmonary hypertension) was found to be
statistically not significant (p>0.05).
CONCLUSION: There was no statistically significant difference seen in the age, gender, hemoglobin level, serum creatinine level,
body mass index, systolic and diastolic blood pressure between the non-pulmonary hypertension and pulmonary hypertension
patients.


Keywords


Hypertension, Chronic kidney disease, Nonpulmonary hypertension, Pulmonary hypertension, Cardiovascular complications.

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References


Veerappan I, Abraham G. Chronic kidney disease: Current status, challenges and management in India. Ch. 130. Available from: http://www.apiindia.org/medicine_update_2013/chap130.pdf. Accessed on 05.04.2017.

Pabst S, Hammerstingl C, Hundt F, Gerhardt T, Grohé C, Nickenig G, et al. Pulmonary Hypertension in Patients with Chronic Kidney Disease on Dialysis and without Dialysis: Results of the PEPPER-Study. PloS one. 2012;7(4):e35310.

Nakhoul F, Yigla M, Gilman R, Reisner SA, Abassi Z. The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access.Nephrology Dialysis Transplantation. 2005;20(8):1686-92.

Zoccali C. Pulmonary hypertension in dialysis patients: a prevalent, risky but still uncharacterized disorder. Nephrology Dialysis Transplantation. 2012;27(10):3674-7.

Patel P, Abraham G, Pratap B, Ramalakshmi R, Mathew M, Jeevan JM, et al. Clinical and biochemical parameters in chronic kidney disease with pulmonary hypertension. Indian Journal of Nephrology. 2007;17(1):4.

Okura H, Takatsu Y. High-Output Heart Failure as a Cause of Pulmonary Hypertension. Internal Medicine. 1994;33(6):363-5.

Guazzi MD, Polese A, Bartorelli A, Loaldi A, Fiorentini C. Evidence of a shared mechanism of vasoconstriction in pulmonary and systemic circulation in hypertension: a possible role of intracellular calcium. Circulation. 1982;66(4):881-6.

Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, et al. Updated Clinical Classification of Pulmonary Hypertension. Journal of the American College of Cardiology. 2009;54(1):S43-S54.

Badesch DB, Champion HC, Gomez Sanchez MA, Hoeper MM, Loyd JE, Manes A, et al. Diagnosis and Assessment of Pulmonary Arterial Hypertension. Journal of the American College of Cardiology. 2009;54(1):S55-S66.

Amin M, Fawzy A, Hamid MA, Elhendy A. Pulmonary Hypertension in Patients With Chronic Renal Failure. Chest. 2003;124(6):2093-7.

Tarrass F, Benjelloun M, Hachim K, Benghanem MG, Ramdani B. Pulmonary hypertension in patients with end-stage renal disease. Indian J Nephrol. 2005;15:223-6

Agarwal R. Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients. Nephrology Dialysis Transplantation. 2012;27(10):3908-14.


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