IMPACT OF BUPRENORPHINE ON QUALITY OF LIFE, HORMONAL LEVELS AND SEXUAL FUNCTIONS IN POST/DODA USER ; A PROSPECTIVE STUDY FROM WESTERN RAJASTHAN

Dr. Om Prakash Dudi, Dr Parth Singh Meena

Abstract


Introduction

Buprenorphine is a new drug for maintenance therapy of opioid dependence. Aside from its role in harm reduction it may potentially enhances client’s quality of life. This study aims to identify the impact of Buprenorphine as a substitution therapy  on clients’ quality of life,hormonal level and sexual life after 6 weeks in treatment .

Methods

In this prospective study , 102 subjects from my private clinic were selected. The raw score from the WHO Quality of Life questionnaire (WHOQOL-BREF), at baseline and 6week of buprenorphine therapy were collected and converted to 0–100 scale form to give quality of life scores for four domains; physical, psychological, social, relationships and environment. Other variables of interest were socio-demography, age when joining therapy, age and duration of illicit ,drug use, sexual dysfunction were collected . Statistical analysis used the SPSS version 16.

Results

The results showed significant positive mean differences in all four domains with p values ≤ 0.001. The largest mean difference was for psychological domain, with mean improvement of 14.84 ± 20.88. Social domain showed the least improvement in WHOQOL scores (6.34 ± 18.80).On Beck depression inventory (BDI) there was significant difference after 6week of therapy (p=.0008) .There was  significant difference in levels of serum Testosterone, Estradiol andProlactin . Serum AST( aspartate aminotransferase) decreased from 33.5 ± 8.2 to  29.1 ± 6.4  with p value of less than 0.0001.

Conclusions

There was a significant improvement in the quality of life and sexual life of  individuals who remained in the programme for  6 weeks.


Keywords


Papaversomnifarum obtained exudate aphrodiasicalong

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References


Jaffe JH, Martin WR. Opioid analgesics and antagonists. In: Gilman AG, Goodman LS, editors. The pharmacological basis of therapeutics. 8. New Jersey: Riverside; 1990. pp. 485–521. [Ref list]

.Nicholls L, Bragaw L, Ruetsch C: Opioid dependence treatment and guidelines. J Manag Care Pharm. 2010, 16 (1-b): S14-S21.PubMedGoogle Scholar

Purohit DR, Vyas BR, Limba PR. Opium de-addiction camp II. J Clin Psychiatry India. 1982;6:98–106.

Purohit DR. Community approach to opium dependent subjects in rural area of Rajasthan. J Community Psychiatry. 1988;11:3–5.

Ganguly KK, Sharma HK, Krishnamachari KA. An ethnographic account of opium consumers of Rajasthan (India): socio-medical perspective. Addiction. 1995;90(1):9–12. doi: 10.1111/j.1360-0443.1995.tb00998.x. [PubMed] [Cross Ref]

Ruchisoni et al ,Psychiatric morbidity, quality of life and marital satisfaction among spouse of men with opioid dependence syndrome: a study from North India,http://www.ijmedicine.com/index.php/ijam/article/viewFile/580/537

Fitzpatrick R, Fletcher A, Gore S, Jones D, Spiegelhalter D, Cox D: Quality of life measures in health care. I: Applications and issues in assessment. BMJ. 1992, 305: 1074-1077. 10.1136/bmj.305.6861.1074.PubMed CentralViewArticlePubMedGoogle Scholar

Quality of life and health: concepts, methods and applications. Edited by: Guggenmoos-Holzmann I, Bloomfield K, Brenner H, Flick U. 1995, Oxford: Blackwell ScienceGoogle Scholar

Carr AJ, Gibson B, Robinson PG: Measuring quality of life: Is quality of life determined by expectations or experience?. BMJ. 2001, 322: 1240-1243. 10.1136/bmj.322.7296.1240.PubMed CentralViewArticlePubMedGoogle Scholar

WHO: Proposal for the inclusion of Methadone in the WHO model list of essential medicines. 2004, Geneva: World Health Organization,http://www.who.int/substance_abuse/activities/methadone_essential_medicines.pdf,Google Scholar

Ward J, Hall W, Mattick RP: Role of maintenance treatment in opioid dependence. Lancet. 1999, 353: 221-226. 10.1016/S0140-6736(98)05356-2.View ArticlePubMedGoogle Scholar.

Daniell HW 2002 Narcotic-induced hypogonadism during therapy for heroin addiction. J Addict Dis 21:47–53

Singh HH, Purohit V, Ahluwalia BS 1982 Methadone blocks dopaminemediated release of gonadotropins in rat hypothalamus. Neuroendocrinology 34:347–352

Chang KJ, Cooper BR, Hazum E, et al. Multiple opiate receptors: different regional distribution in brain and differential binding of opiates and opioid peptides. MolPharmacol. 1979;16:91–104. [PubMed]

Walsh SL, Eissenberg T 2003 The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic. Drug Alcohol Depend 70(Suppl 2):S13–S27

SharifaEzat W, Noor Azimah H, Rushidi R, Raminder K, Ruhani I: Compliance towards methadone maintenance therapy and its associated factors in Selangor primary care centers and Kuala Lumpur hospital. Med J Malaysia. 2009, 64: 65-70.PubMedGoogle Scholar

Daniell HW 2002 Narcotic-induced hypogonadism during therapy for heroin addiction. J Addict Dis 21:47–53.

Saxena S, Chandiramani K, Bhargava R. WHOQOL-Hindi: A questionnaire for assessing quality of life in health care settings in India. World Health Organization Quality of Life. Natl Med J India. 1998;11:160–5. [PubMed]

Sathvik BS, Parthasarathi G, Narahari MG, Gurudev KC. An assessment of the quality of life in hemodialysis patients using the WHOQOL-BREF questionnaire. Indian J Nephrol. 2008;18:141–9.[PMC free article] [PubMed]

Pacian A, Kulik TB, Pacian J, Chrusciel P, Zolnierczuk-Kieliszek D, Jarosz MJ. Psychosocial aspect of quality of life of Polish women with breast cancer. Ann Agric Environ Med. 2012;19:509–12. [PubMed]

Khosravi A, Ramezani MA, Toghianifar N, Rabiei K, Jahandideh M, Yousofi A. Association between hypertension and quality of life in a sample of Iranian adults. ActaCardiol. 2010;65:425–30. [PubMed]

de Oliveira PP, Sandrin CC, Batista PH, Marinheiro LP, Wender MC, Roisenberg F. Relationship between quality of life and vertebral fracture in older women living in Southern Brazil. Rev Bras Ginecol Obstet. 2011;33:231–7. [PubMed]

The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva: World Health Organization; 1992.

Nizam Baharom et al Improvement of quality of life following 6 months of methadone maintenance therapy in Malaysia Substance Abuse Treatment, Prevention, and Policy20127:32 ,https://doi.org/10.1186/1747-597X-7-32

McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM, et al. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 2000; 26 : 25-40.

Mathur ML, Bansal RK, Dixit AK. Prevalence of opium consumption in rural population of a desert district, Jodhpur. Indian J Public Health. 1991;35(4):117–118. [PubMed]

DeMaeyer J, Vanderplasschen W, Broekaert E: Quality of life among opiate-dependent individuals: A review of the literature. International Journal of Drug Policy. 2010, 21: 364-380. 10.1016/j.drugpo.2010.01.01View ArticlePubMedGoogle Scholar

Huong AGW, Ng CG, Amer SA: Quality of life assessment of opioid substance abusers on methadone maintenance therapy (MMT) in University Malaya Medical Centre. ASEAN Journal of Psychiatry. 2009, 10: 1-11.Google Scholar

Padaiga Z, Subata E, Vanagas G: Outpatient methadone maintenance treatment program. Quality of life and health of opioid-dependent persons in Lithuania. Medicina (Kaunas). 2007, 43: 235-241.Google Scholar

Xiao L, Wu z, Luo W, Wei X: Quality of life of outpatients in Methadone Maintenance Treatment clinics. J Acquir Immune DeficSyndr. 2010, 53: S116-S120.PubMed CentralViewArticlePubMedGoogle Scholar

Torrens M, Domingo-Salvany A, Alonso J, Castillo C, San L: Methadone and quality of life. Lancet. 1999, 353: 1101-View ArticlePubMedGoogle Scholar.


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