SPECTRUM OF COMPLICATIONS IN HAEMOGLOBINOPATHIES-A STUDY IN CENTRAL INDIA

Khaire Prabha B, Dahyalkar Amol A, Babasaheb suroshe, Smita mundada

Abstract


INTRODUCTION: Thalassemias are hereditary hemolytic anemia with autosomal recessive inheritance characterized by inability
to produce one or more globin chains forming hemoglobin molecule.
MATERIAL AND METHODS: Prospective observational study conducted at tertiary care hospital from January 2015 - November
2016.Total187 patients of haemoglobinopathies satisfying the inclusion and exclusion criteria were enrolled. Detailed histories
with clinical examination were noted in preformed structural proforma.
RESULTS: Complication rates were significantly higher among thalassemia major patients compared to other
haemoglobinopathy. Stunting in thalassemia major group160 (85.5%), sickle cell disease 11(91.6%), splenomegaly was noticed
in 141(75.4%).Cardiac complication 16(8.5%), most common complication was Congestive cardiac failure 10 (5.8%) cases,
followed by Early transfusion reaction in 9 (5.2%), and infection (sepsis and bronchopneumonia) was seen in 6(3.5%).
CONCLUSION: Complication were Stunting, splenomegaly, Congestive cardiac failure, Early transfusion reaction, and Infection
(sepsis and bronchopneumonia) seen.


Keywords


Haemoglobinopathies, Cardiac complication,Infection.

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References


Chattopadhyay et al an epidemiological study on the clinicohaematological profile of patients of congenital haemolytic anemia in a tertiary care hospital,Kolkata. Indian J. Prev. Soc. Med. Vol. 43 No.4, 2012

Amitatrehan et alClinicoinvestigational and Demographic Profile of Children with Thalassemia MajorIndian J Hematol Blood Transfus (Jan-Mar 2015) 31(1):121–126 DOI 10.1007/s12288-014-0388-y

Cunningham MJ, Sankaran VG, Nathan DG, Orkin SH. The Thalassemias. In: Orkin SH, Nathan DG, Ginsburg D, Look AT. Nathan and Oski’s Hematology of Infancy and Childhood, 7th ed. Philadelphia: Sounders Elsevier; 2009:1015-1109

IAP Growth charts, http://www.iapindia.org/page.php,id=79.

WHO Growth standards. http://www.who.int/childgrowth/standards/en.

eMedicineHealth (2011): Enlarged splee. URL-http://www. emedicinehealth. com / enlarged_spleen_ splenomegaly/article_em.htm

chopra et al Spectrum of haemoglobinopathies in tertiary care hospital,armedChattopadhyay et al an epidemiological study on the clinicohaematological profile of patients of congenital haemolytic anemia in a tertiary care hospital,Kolkata. Indian J. Prev. Soc. Med. Vol. 43 No.4, 2012

Kwan EY, Lee AC, Li AM, Tam SC, Chan CF, Lau YL, et al. A cross-sectional study of growth, puberty and endocrine function in patients with thalassaemia major in Hong Kong. J Paediatr Child Health. 1995 Apr;31(2):83-7.

Ayhanyaman et al Common complications in beta thalasseiapatients,international journal of hematology and oncology,turkey;nov3,vol23;2013

Varshawankhade et al,Diverse Clinical manifestations in Sickle Cell Anemia: study in District Amravati, MS India.J Blood dis.trans.2013,4:1

Diptyjain et al Efficacy of Fixed Low Dose Hydroxyurea in Indian Children with Sickle Cell Anemia: A Single Centre Experience,Indian paediatrics;2013

Vichinsky et al. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000;342(25):1855-65. [Erratum appears in N Engl J Med. 2000 Sep 14;343(11):824].

F.UR.Khan Frequency of complications in Beta Thalassemia major in D.I.KHANE:/Biomedica/Vol.23Jan Bio-5.-Jun.2007/


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