Can you masturbate with conditioner? Shampoo, conditioner, soap, and hand lotion all include chemicals that may irritate the penile skin if used as a lubrication during masturbation. Rash, swelling, itching, and dry, peeling skin are all potential effects. Instead, you should use a lubricant that is water-based and has no additional smells. Afterward, wash it off and use a penis health crème to calm irritated skin and restore its natural moisture. Regular masturbation may cause the penile skin to become insensitive and a penis cream can help alleviate this problem.